The State Research Center of Industrialization for Crystallization Technology (SRCICT) was founded as the first, and up to da...

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龚俊波,男,1974年出生,博士,教授,博士生导师

电话:86-22-27405754
传真:86-22-27374971
地址:天津市南开区卫津路92号
邮编:300072
E-mail:junbo_gong@tju.edu.cn

1995年获天津大学工业化学与技术经济双学士学位;2001年获天津大学化学工程博士学位。2006至2008年在美国密歇根大学药学院从事博士后研究。现为天津大学化工学院国家工业结晶工程技术研究中心副主任,化学工程系副主任。


讲授课程:
1、化工设计(本科生)
2、化工过程模拟(本科生)
3、分子科学与工程信息学(本科生)
4、工业结晶与粒子过程(研究生)


课题成果:
1. 国家创新药物重大专项:药物晶型优化及产业化技术
2. 科技部国际合作重大项目:药物超分子组装、调控和高效化传送系统基础研究
3. 国家自然科学基金:溶剂介导药物晶型转化的过程研究
4. 天津市自然科学基金:药物多晶型在溶液中的转晶机理研究
5. 教育部博士点新教师基金:有机药物共晶基础研究
6. 863计划子课题:生物制造分离过程技术与装备(工业结晶过程与装备)
7. 863计划子课题:柠檬酸、葡萄糖酸生物转化(柠檬酸和葡萄糖酸结晶技术)
8. 国家重点实验室开放基金:基于过程分析技术和流体力学模型的工业结晶设计
9. 国家自然科学重点基金:分子仿生调控药物结晶的作用机理与过程强化研究
10. 天津市自然科学重点基金:药物共晶超分子组转与调控机理研究
11. 产学研合作项目:生物制药、糖和糖醇、有机生物农药和兽药、精细化工和石化产品 等

科研简介:
主要研究方向:药物结晶与粒子过程,工业结晶技术与设备,生物产品化工分离与精制等。
1.研究工业结晶过程的多尺度机制关联与调控,针对工业结晶过程的非线性、非稳态和滞后性等复杂问题,开展从分子模拟、界面结构、过程分析到系统集成优化的多尺度研究。
2.药物多晶型理论与实践应用研究,针对化学药物与生物技术药物的多晶型问题,研究药物晶型与其生物利用度、生物活性、溶解性、稳定性等药物特性之间的关系,研发药物特定目的晶型产品的结晶产业化技术。
3.现代药物传送系统设计与开发的基础研究,利用晶体工程学的理论和方法,开展了药物超分子组装、调控和高效化传送系统的研究,主要课题包括磁性四氧化三铁纳米粒子的组装、调控及其性质研究以及介孔二氧化硅材料载药性能和结构改性等方面的研究。

研究生培养:
培养研究生 9 名,协助培养博士后4 名,博士生6 名,他们都已经工作在国内外各大药企、研究院和设计院,目前课题组成员:


发表论文:
发表论文54 篇,其中SCI 论文36 篇;申请和授权国家发明专利14 项。近两年发表论文:
1. Xiujuan Li, Si Chang, Guangsheng Du, Junbo Gong, Zhenping Wei. Encapsulation of azithromycin into polymeric microspheres by reduced pressure-solvent evaporation method. International Journal of Pharmaceutics, Accepted.
2. Jingmei Hou, Ruiyan Li, Songgu Wu, Junbo Gong. The induction time, interfacial energy and growth mechanism of maltitol in batch cooling crystallization, CRYSTAL RESEARCH AND TECHNOLOGY, Accepted.
3. Ruiyan Li, Junbo Gong. Correlation of Solubility and Prediction of the Mixing Properties of Ginsenoside Compound K in Various Solvents, Industrial and Engineering Chemistry Research, Accepted.
4. Songgu Wu, Junbo Gong. Experimental determination of the solid liquid equilibrium, metastable zone, and nucleation parameters of the flunixin meglumine-ethanol system, Journal of Crystal Growth, Accepted.
5. Zhang Mianzhi; Liu Miao; Xiong Min; Gong Junbo. Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy. Journal of ethnopharmacology, 2012, 141(1): 111-118.
6. Li Runyan; Dong Weibing; He Huining; Gong Junbo. Isolation, characterization and phase transformation of new ginsenoside compound k hydrate and methanol solvates. CRYSTAL RESEARCH AND TECHNOLOGY, 2012, 47(4): 377-384.
7. Zhang, X., Yin, Q., Cui, P., Liu, Z., Gong, J. Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents. Industrial and Engineering Chemistry Research, 2012, 51(19): 6933-6938.
8. Wu Songgu; Jiang Xiaobin; Dong Weibing; Gong Junbo. Phase Equilibria, Crystallization, and Microstructural Studies of the Flunixin Meglumine plus Meglumine System. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2012, 57(1): 204-207.
9. David Allan E.; Gong Junbo; Chertok Beata; etc.. Immobilized thermolysin for highly efficient production of low-molecular-weight protamine-An attractive cell-penetrating peptide for macromolecular drug delivery applications. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2012, 100A(1): 211-219.
10. Zhang Jinli; Liu Anyuan; Han You; Gong Junbo. Effects of Self-Assembled Monolayers on Selective Crystallization of Tolbutamide. CRYSTAL GROWTH & DESIGN, 2011, 11(12): 5498-5506.
11. Hu Jiajia; Qin Kunhua; Zhang Yan; Gong Junbo. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011, 411(4): 786-791.
12. Yan, H., Li, R., Li, Q., Wang, J., Gong Junbo. Solubility of minoxidil in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and water from (278.15 to 333.15) K, Journal of Chemical and Engineering Data, 2011, 56 (5): 2720-2722.
13. Cui, P., Yin, Q., Gong Junbo. Solubility of candesartan cilexetil in different solvents at various temperatures, Journal of Chemical and Engineering Data, 2011, 56 (3): 658-660.
14. Song, L., Gao, Y., Gong, J. Measurement and correlation of solubility of clopidogrel hydrogen sulfate (Metastable Form) in lower alcohols, Journal of Chemical and Engineering Data, 2011, 56 (5): 2553-2556.
15. Wang, P., Wang, J., Gong, J., Zhang, M. Determination of the solubility, dissolution enthalpy and entropy of Deflazacort in different solvents, Fluid Phase Equilibria, 2011, 306(2): 171-174.
16.  Zhang, J., Wang, L., Wang, D., Gong, J., Li, W., Wang, J. Solubility of dexibuprofen in different solvents from (263.15 to 293.15) K, Journal of Chemical and Engineering Data, 2011, 56 (3): 671-673.
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